A Scoping Review of Biobehavioural Interventions to Improve PrEP Continuum of Care in Latin America

Resumen

Según la literatura, las intervenciones bioconductuales o estrategias combinadas reducirían el riesgo de infección por VIH en más de 7000 nuevos casos cada día, lo que contribuiría a la batalla que enfrenta América Latina, región en la que, a pesar de la alta incidencia y prevalencia del VIH, el acceso a la PrEP (profilaxis preexposición) es muy limitado. De acuerdo con las directrices de PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), el objetivo de esta investigación fue realizar una revisión de alcance para evaluar la evidencia de los datos de resultados disponibles sobre intervenciones bioconductuales y programas para abordar las brechas en el continuo de atención de PrEP en América Latina. La búsqueda se realizó en las bases de datos EBSCOhost, WoS, Scopus y ProQuest, e incluyó todos los estudios publicados de 2010 a 2021. Se identificaron ciento ochenta y seis estudios, y se evaluaron de acuerdo con los criterios de elegibilidad en seis etapas, iniciando por la eliminación de duplicados hasta la selección de estudios que cumplieran los criterios previamente mencionados; al final se eligieron cinco estudios, los cuales fueron sometidos a la evaluación de calidad metodológica, incluyendo el cumplimiento de los lineamientos éticos. Los resultados muestran que las intervenciones bioconductuales que promueven la PrEP en América Latina son efectivas para aumentar el uso del condón, disminuir el riesgo de VIH y aumentar la conciencia, la aceptación, la adherencia y la retención de la PrEP. El número limitado de intervenciones en el continuo de atención de la PrEP indica la necesidad de adoptar marcos científicos de difusión e implementación (D&I); marcos que podrían ayudar a facilitar la traducción de prácticas, intervenciones y políticas basadas en la evidencia para abordar la crisis del VIH en América Latina.

Palabras clave:

VIH PrEP intervenciones bioconductuales América Latina servicios de salud basados en la comunidad PRISMA

Citas

Aarons, G. A., Sklar, M., Mustanski, B., Benbow, N., & Brown, C. H. (2017). “Scaling-Out” Evidence-Based Interventions to New Populations or New Health Care Delivery Systems. Implementation Science, 12, Article 11. https://doi.org/10.1186/s13012-017-0640-6

Baumann, A. A., & Cabassa, L. J. (2020). Reframing Implementation Science to Address Inequities in Healthcare Delivery. BMC Health Services Research, 20, Article 190. https://doi.org/10.1186/s12913-020-4975-3

Biello, K. B., Oldenburg, C. E., Safren, S. A., Rosenberger, J. G., Novak, D. S., Mayer, K. H., & Mimiaga, M. J. (2016). Multiple Syndemic Psychosocial Factors are Associated with Reduced Engagement in HIV Care Among a Multinational, Online Sample of HIV-Infected MSM in Latin America. AIDS Care, 28(sup1), 84-91. https://doi.org/10.1080/09540121.2016.1146205

Blashill, A. J., Brady, J. P., Rooney, B. M., Rodriguez-Diaz, C. E., Horvath, K. J., Blumenthal, J., Morris, S., Moore, D. J., & Safren, S. A. (2020). Syndemics and the PrEP Cascade: Results from a Sample of Young Latino Men Who Have Sex with Men. Archives of Sexual Behavior, 49(1), 125-135. https://doi.org/10.1007/s10508-019-01470-7

Brooks, R. A., Landrian, A., Nieto, O., & Fehrenbacher, A. (2019). Experiences of Anticipated and Enacted Pre-exposure Prophylaxis (PrEP) Stigma among Latino MSM in Los Angeles. AIDS and Behavior, 23(7), 1964-1973. https://doi.org/10.1007/s10461-019-02397-9

Centers for Disease Control and Prevention (CDC). (2015). The Social-Ecological Model: A Framework for Prevention. https://www.cdc.gov/violenceprevention/about/social-ecologicalmodel.html

Chou, R., Evans, C., Hoverman, A., Sun, C., Dana, T., Bougatsos, C., Grusing, S., & Korthuis, P. T. (2019). Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 321(22), 2214-2230. https://doi.org/10.1001/jama.2019.2591

Clark, J., Reisner, S., Perez-Brumer, A., Huerta, L., Sanchez, H., Moriarty, K., Luque, M. M., Okochi, H., Salazar, X., Mimiaga, M., Sanchez, J., Gandhi, M., Mayer, K. H., &

Lama, J. R. (2021). TransPrEP: Results from the Pilot Study of a Social Network-Based Intervention to Support PrEP Adherence Among Transgender Women in Lima, Peru. AIDS and Behavior, 25(6), 1873-1883. https://doi. org/10.1007/s10461-020-03117-4

Cordova, D., Munoz-Velazquez, J., Lua, F. M., Fessler, K., Warner, S., Delva, J., Adelman, N., Fernandez, A., & Bauermeister, J. (2020). Pilot Study of a Multilevel Mobile Health app for Substance Use, Sexual Risk Behaviors, and Testing for Sexually Transmitted Infections and HIV among Youth: Randomized Controlled Trial. JMIR MHealth and UHealth, 8(3), Article e16251 https://doi.org/10.2196/16251

Dehlin, J. M., Stillwagon, R., Pickett, J., Keene, L., & Schneider, J. A. (2019). # PrEP4Love: An Evaluation of a Sex-Positive HIV Prevention Campaign. JMIR Public Health and Surveillance, 5(2), Article e12822. https://doi.org/10.2196/12822

Deutsch, M. B., Glidden, D. V, Sevelius, J., Keatley, J., McMahan, V., Guanira, J., Kallas, E. G., Chariyalertsak, S., & Grant, R. M. (2015). HIV Pre-Exposure Prophylaxis in Transgender Women: A Subgroup Analysis of the iP-rEx Trial. The Lancet HIV, 2(12), e512-e519. https://doi.org/10.1016/S2352-3018(15)00206-4

Diaz, J. (2018). Contextualizing HIV Risk Among Latino Men who Have Sex with Men: The Role of Cultural, Spatial, and Syndemic Factors [Doctoral Thesis, Columbia University]. Columbia University Libraries https://doi.org/10.7916/D8FX8NXC

Downes, M. J., Brennan, M. L., Williams, H. C., & Dean, R. S. (2016). Development of a Critical Appraisal Tool to Assess the Quality of Cross-Sectional Studies (AXIS). BMJ Open, 6(12), Article e011458. https://doi.org/10.1136/bmjopen-2016-011458

Glick, J. L., Russo, R., Jivapong, B., Rosman, L., Pelaez, D., Footer, K. H. A., & Sherman, S. G. (2019). The PrEP Care Continuum among Cisgender Women who Sell Sex and/or Use Drugs Globally: A Systematic Review. AIDS and Behavior, 24(5), 1312-1333. https://doi.org/10.1007/s10461-019-02733-z

Grant, R. M., Anderson, P. J., McMahan, V., Liu, A. Y., Amico, K. R., Mehrotra, M., Hosek, S. G., Mosquera, C., Casapia, M., Montoya, O., Buchbinder, S., Veloso, V. G., Mayer, K. H., Chariyalertsak, S., Bekker, L., Kallas, E. G., Schechter, M., Guanira, J. V., Bushman, L. R., . . . Glidden, D. V. (2014). Uptake of Pre-Exposure Prophylaxis, Sexual Practices, and HIV Incidence in Men and Transgender Women who Have Sex with Men: A Cohort Study. Lancet Infectious Diseases, 14(9), 820-829. https://doi.org/10.1016/s1473-3099(14)70847-3

Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., Goicochea, P., Casapía, M., Guanira-Carranza, J. V., Ramirez-Cardich, M. E., Montoya- Herrera, O., Fernández, T., Veloso, V. G., Buchbinder, S. P., Chariyalertsak, S., Schechter, M., Bekker, L.-G., Mayer, K. H., Kallás, E. G., ... Glidden, D. V. (2010). Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men. New England Journal of Medicine, 363(27), 2587-2599. https://doi.org/10.1056/NEJMoa1011205

Grinsztejn, B., Hoagland, B., Moreira, R. I., Kallas, E. G., Madruga, J. V, Goulart, S., Leite, I. C., Freitas, L., Martins, L. M. S., Torres, T. S., Vasconcelos, R., De Boni, R. B., Anderson, P. L., Liu, A., Luz, P. M., & Veloso, V. G. (2018). Retention, Engagement, and Adherence to Pre-Exposure Prophylaxis for Men Who Have Sex with Men and Transgender Women in PrEP Brasil: 48 Week Results of a Demonstration Study. The Lancet HIV, 5(3), e136-e145. https://doi.org/10.1016/S2352-3018(18)30008-0

Hillis, A., Germain, J., Hope, V., McVeigh, J., & Van Hout, M. C. (2020). Pre-Exposure Prophylaxis (PrEP) for HIV Prevention Among Men Who Have Sex with Men (MSM): A Scoping Review on PrEP Service Delivery and Programming. AIDS and Behavior, 24(11), 3056-3070. https://doi.org/10.1007/s10461-020-02855-9

Hoagland, B., Moreira, R. I., De Boni, R. B., Kallas, E. G., Madruga, J. V., Vasconcelos, R., Goulart, S., Torres, T. S., Marins, L. M. S., Anderson, P. L., Luz, P. M., Da Costa Leite, U., Liu, A. Y., Veloso, V. G., & Grinsztejn, B. (2017). High Pre-Exposure Prophylaxis Uptake and Early Adherence among Men who Have Sex with Men and Transgender Women at Risk for HIV Infection: The PrEP Brasil Demonstration Project. Journal of the International AIDS Society, 20(1), 21472. https://doi. org/10.7448/IAS.20.1.21472

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2018). Miles to Go. The Response to HIV in Latin America (p. 58). UNAIDS Geneva. https://www.unaids.org/sites/default/files/media_asset/miles-to-go_latin-america_en.pdf

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2019a). Global AIDS Update 2019—Communities at the Centre. UNAIDS Geneva. https://www.unaids.org/sites/default/files/media_asset/2019-global-AIDS-update_en.pdf

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2019b). Power to the People (p. 100). UNAIDS Geneva. https://reliefweb.int/sites/reliefweb.int/files/resources/power-to-the-people_en_0.pdf

Joint United Nations Programme on HIV/AIDS(UNAIDS). (2020). UNAIDS DATA 2020. https://

www.unaids.org/sites/default/files/media_asset/2020_aids-data-book_en.pdf

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2021). UNAIDS data 2021. https://www.unaids.org/en/resources/documents/2021/2021_unaids_data

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2022a). Global AIDS update 2022. https://www.unaids.org/sites/default/files/media_asset/2022-global-aids-update_en.pdf

Joint United Nations Programme on HIV/AIDS (UNAIDS). (2022b). Monitoreo global del SIDA 2022. Indicadores y preguntas para el seguimiento de los progresos de la Declaración Política sobre el VIH y el SIDA de 2021. ONUSIDA. https://www.unaids.org/sites/default/files/media_asset/global-aids-monitoring_es.pdf

Lewin, S., Glenton, C., & Oxman, A. D. (2009). Use of Qualitative Methods Alongside Randomised

Controlled Trials of Complex Healthcare Interventions: Methodological Study. Bmj, 339, Article b3496. https://doi.org/10.1136/bmj.b3496

Liu, A. Y., Vittinghoff, E., von Felten, P., Rivet Amico, K., Anderson, P. L., Lester, R., Andrew, E., Estes, I., Serrano, P., Brothers, J., Buchbinder, S., Hosek, S., & Fuchs, J. D. (2019). Randomized Controlled Trial of a Mobile Health Intervention to Promote Retention and Adherence to Preexposure Prophylaxis Among Young People at Risk for Human Immunodeficiency Virus: The EPIC Study. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 68(12), 2010-2017. https://doi.org/10.1093/cid/ciy810

Longino, A., Montano, M. A., Sanchez, H., Bayer, A., Sanchez, J., Tossas-Milligan, K., Duerr, A., & Molina, Y. (2020). Increasing PrEP Uptake and Adherence among MSM and TW Sex Workers in Lima, Perú: What and Whom Do Different Patients Trust? AIDS Care, 32(2), 255-260. https://doi.org/10.1080/09540121.2019.1634787

Luz, P. M., Benzaken, A., Alencar, T. M. de, Pimenta, C., Veloso, V. G., & Grinsztejn, B. (2018). PrEP Adopted by the Brazilian National Health System: What is the Size of the Demand? Medicine, 97(1S), S75-S77. https://doi.org/https://doi.org/10.1097/MD.0000000000010602

Luz, P. M., Veloso, V. G., & Grinsztejn, B. (2019). The HIV Epidemic in Latin America: Accomplishments and Challenges on Treatment and Prevention. Current Opinion in HIV and AIDS, 14(5), 366-373. https://doi.org/10.1097/COH.0000000000000564

Marcus, J. L., Buisker, T., Horvath, T., Amico, K. R., Fuchs, J. D., Buchbinder, S. P., Grant, R. M., & Liu, A. Y. (2014). Helping our Patients Take HIV Pre-Exposure Prophylaxis (PrEP): A Systematic Review of Adherence Interventions. HIV Medicine, 15(7), 385-395. https://doi.org/10.1111/hiv.12132

Marins, L. M. S., Torres, T. S., Leite, I. da C., Moreira, R. I., Luz, P. M., Hoagland, B., Kallas, E. G., Madruga, J. V., Liu, A. Y., Anderson, P. L., Grinsztejn, B., & Veloso, V. G. (2019). Performance of HIV pre-Exposure Prophylaxis Indirect Adherence Measures among Men who Have Sex with Men and Transgender Women: Results from the PrEP Brasil Study. PLoS ONE, 14(8), Article e0221281. https://doi.org/10.1371/journal.pone.0221281

Martinez, O., Arreola, S., Wu, E., Muñoz-Laboy, M., Levine, E. C., Rutledge, S. E., Hausmann-Stabile, C., Icard, L., Rhodes, S. D., Carballo-Diéguez, A., Rodríguez-Díaz, C. E., Fernández, M. I., & Sandfort, T. (2016). Syndemic Factors Associated with Adult Sexual HIV Risk Behaviors in a Sample of Latino Men who Have Sex with Men in New York City. Drug and Alcohol Dependence, 166, 258-262. https://doi.org/10.1016/j.drugalcdep.2016.06.033

Martinez, O., Brady, K. A., Levine, E., Page, K. R., Zea, M. C., Yamanis, T. J., Grieb, S., Shinefeld, J., Ortiz, K., Davis, W. W., Mattera, B., Martinez-Donate, A., Chavez-Baray, S., Moya, E. M. (2020). Using Syndemics Theory to Examine HIV Sexual Risk among Latinx Men Who Have Sex with Men in Philadelphia, PA: Findings from the National HIV Behavioral Surveillance. EHQUIDAD. Revista Internacional de Políticas de Bienestar y Trabajo Social, (13), 217-236. https://doi.org/10.15257/ ehquidad.2020.0009

McLaughlin, M. L., Hou, J., Meng, J., Hu, C.-W., An, Z., Park, M., & Nam, Y. (2016). Propagation of Information about Preexposure Prophylaxis (PrEP) for HIV Prevention through Twitter. Health Communication, 31(8), 998-1007. https://doi.org/10.1080/10410236.2015.1027033

Mimiaga, M. J., Biello, K. B., Robertson, A. M., Oldenburg, C. E., Rosenberger, J. G., O’Cleirigh, C., Novak, D. S., Mayer, K. H., & Safren, S. A. (2015). High Prevalence of Multiple Syndemic Conditions Associated with Sexual Risk Behavior and HIV Infection Among a Large Sample of Spanish- and Portuguese-Speaking Men Who Have Sex with Men in Latin America. Archives of Sexual Behavior, 44(7), 1869-1878. https://doi.org/10.1007/s10508-015-0488-2

Molina, J., Charreau, I., Spire, B., Cotte, L., Chas, J., Capitant, C., Tremblay, C., Rojas-Castro, D., Cua, E., Pasquet, A., Bernaud, C., Pintado, C., Delaugerre, C.,Sagaon-Teyssier, L., Mestre, S. L., Chidiac, C., Pialoux, G., Ponscarme, D., Fonsart, J., . . . Rabian, C. (2017). Efficacy, Safety, and Effect on Sexual Behaviour of On-Demand Pre-Exposure Prophylaxis for HIV in Men who Have Sex with Men: An Observational Cohort Study. The Lancet HIV, 4(9), e402-e410. https://doi.org/10.1016/s2352-3018(17)30089-9

Morne, J. E., Tesoriero, J. M., Martin, E. G., Birkhead, G. S., Holtgrave, D. R., Hagos, K., & Zucker, H. (2020). Ending the HIV Epidemic: New York’s Quest to Become the First State to Reduce HIV Prevalence. Public Health Reports, 135(1_suppl), 65S-74S. https://doi.org/10.1177/0033354920917403

Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2018). Systematic Review or Scoping Review? Guidance for Authors when Choosing between a Systematic or Scoping Review Approach. BMC Medical Research Methodology, 18(1), Article 143. https://doi.org/10.1186/s12874-018-0611-x

Mustanski, B., Ryan, D. T., Hayford, C., Phillips II, G., Newcomb, M. E., Smith, J. D. (2018). Geographic and Individual Associations with PrEP Stigma: Results from the RADAR Cohort of Diverse Young Men Who Have Sex with Men and Transgender Women. AIDS and Behavior, 22(9), 3044-3056. https://doi.org/10.1007/s10461-018-2159-5

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T., Mulrow, C. D., Shamseer, L., Tetzlaff, J., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E., Mayo-Wilson, E., McDonald, S., . . . Moher, D. (2021). The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews. BMJ, 372, Article n71. https://doi.org/10.1136/bmj.n71

Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., ...McKenzie, J. E. (2021). PRISMA 2020 Explanation and Elaboration: Updated Guidance and Exemplars for Reporting Systematic Reviews. BMJ, 372, Article n160.https://doi.org/10.1136/bmj.n160

Patel, V. V. V, Ginsburg, Z., Golub, S. A. A., Horvath, K. J. J., Rios, N., Mayer, K. H. H., Kim, R. S. S., & Arnsten, J. H. H. (2018). Empowering with PrEP (E-PrEP), a Peer-Led Social Media-Based Intervention to Facilitate HIV Preexposure Prophylaxis Adoption among Young Black and Latinx Gay and Bisexual Men: Protocol for a Cluster Randomized Controlled Trial. Journal of Medical Internet Research, 7(8), Artícle e11375. https://doi.org/10.2196/11375

Peters, M. D. J., Marnie, C., Tricco, A. C., Pollock, D., Munn, Z., Alexander, L., McInerney, P., Godfrey, C. M., & Khalil, H. (2020). Updated Methodological Guidance for the Conduct of Scoping Reviews. JBI Evidence Synthesis, 18(10), 2119-2126. https://doi.org/https://doi.org/10.11124/JBIES-20-00167

Peters, M., Godfrey, C., McInerney, P., Munn, Z., Tricco, A., & Khalil, H. (2020). Scoping Reviews (2020 version). In E.Aromataris, Z. Munn (Ed.), JBI Manual for Evidence Synthesis. JBI. https://doi.org/10.46658/JBIMES-20-12

Ravasi, G., Grinsztejn, B., Baruch, R., Guanira, J. V, Luque, R., Cáceres, C. F., & Ghidinelli, M. (2016). Towards a fair Consideration of PrEP as Part of Combination HIV Prevention in Latin America. Journal of the International AIDS Society, 19(Suppl 6), Article 21113. https://doi.org/10.7448/IAS.19.7.21113

Samuel, K. (2019). Same-Day Initiation of PrEP Feasible and Safe in Latin America. 10th International AIDS Society Conference on HIV Science (IAS 2019). https:// www.aidsmap.com/news/jul-2019/same-day-initiation-prep-feasible-and-safe-latin-america

Schnarrs, P. W., Gordon, D., Martin-Valenzuela, R., Sunil, T., Delgado, A. J., Glidden, D., Parsons, J. T., & McAdams, J. (2018). Perceived Social Norms About Oral PrEP Use: Differences Between African-American, Latino and White Gay, Bisexual and Other Men Who Have Sex with Men in Texas. AIDS and Behavior, 22(11), 3588-3602. https://doi.org/10.1007/s10461-018-2076-7

Shoptaw, S., Goodman-Meza, D., & Landovitz, R. J. (2020). Collective Call to Action for HIV/AIDS Community-Based Collaborative Science in the Era of COVID-19. AIDS and Behavior, 24(7), 2013-2016. https://doi.org/10.1007/s10461-020-02860-y

Tanner, A. E., Song, E. Y., Mann-Jackson, L., Alonzo, J., Schafer, K., Ware, S., Garcia, J. M., Arellano Hall, E., Bell, J. C., Van Dam, N., & Rhodes, S. D. (2018).

Preliminary Impact of the weCare Social Media Intervention to Support Health for Young Men Who Have Sex with Men and Transgender Women with HIV. AIDS Patient Care and STDs, 32(11), 450-458. https://doi.org/10.1089/apc.2018.0060

Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L. A., Hartling, L., Aldcroft, A., Wilson, M. T., Garritty, C., . . . Straus, S. E. (2018). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine, 169(7), 467-473. https://doi.org/10.7326/m18-0850

Wilson, E. C., Jalil, E. M., Castro, C., Martinez Fernandez, N., Kamel, L., & Grinsztejn, B. (2019). Barriers and facilitators to PrEP for transwomen in Brazil. Global Public Health, 14(2), 300-308. https://doi.org/10.1080/17441692.2018.1505933

Wood, S., Gross, R., Shea, J. A., Bauermeister, J. A., Franklin, J., Petsis, D., Swyryn, M., Lalley-Chareczko, L., Koenig, H. C., & Dowshen, N. (2019). Barriers and Facilitators of PrEP Adherence for Young Men and Transgender Women of Color. AIDS and Behavior, 23(10), 2719-2729. https://doi.org/10.1007/s10461-019-02502-y

World Health Organization. (2016). Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection (2nd ed). World Health Organization. https://www.who.int/publications/i/item/9789241549684

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