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Cortés Salazar, F., Suárez Ortíz, J. O., Cendejas Trejo, N. M., Mancilla Díaz, J. M., López Alonso, V. E., & Escartín Pérez, R. E. (2014). Effects of CB1 cannabinoid receptor activation in the nucleos accumbens shell on feeding behavior. Acta Colombiana De Psicología, 17(2), 61–68.

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Obesity and its related pathologies are well- known health hazards. Although obesity and overweight have multifactorial causes, overeating is common in both of these conditions. According to animal models, endocannabinoids and their receptors in the brain play a key role in the genesis and development of obesity. It has been proposed that the cannabinoid receptors CB1 (RCB1) expressed in the nucleus accumbens shell (NAC) are involved in the increase of the hedonic properties of food. To test this hypothesis, thisstudy aimed to assess the effects of activating the NACs RCB1 on standard food intake during the light phase of the light-dark cycle. The effects of activating the RCB1 with CP 55,940 and WIN 55-212-2 (0.125, 0.25 and 0.5 nmol) in the NACS on feeding behavior and the behavioral satiety sequence of rats were assessed. It wasfound that both agonists increased food intake and delayed expression of satiety during the light phase. These results suggest that cannabinoid agonists encourage food intake when motivation is low and palatability is normal.



Bassareo, V. & Di Chiara, G. (1999). Modulation of feedinginduced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state. European Journal of Neuroscience, 11(12), 4389-4397.

Berner, L. A., Avena, N. M. & Hoebel, B. G. (2008). Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity (Silver Spring) 16,1998-2002.

Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C., Pasquali, R., Lutz, B., Stalla, G. K. & Pagotto, U. (2003). The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation, 112, 423-431.

Di Patrizio, N. V. & Simansky, K. J. (2008). Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats.Journal of Neuroscience, 28(39),9702-9709.

Dimitriou, S. G., Rice, H. B. & Corwin, R. L. (2000). Effects of limited access to a fat option on food intake and body composition in female rats. International Journal of Eating Disorders, 28,436-445.

Drews, E., Schneider, M. & Koch, M. (2005). Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats. Pharmacology Biochemistry and Behavior, 80(1),145-150.

Escartín-Pérez, R. E., Cendejas-Trejo, N. M., Cruz-Martínez, A. M., González-Hernández B., Mancilla-Díaz, J. M. & Florán-Garduño, B. (2009). Role of cannabinoid CB1 receptors on macronutrient selection and satiety in rats. Physiology and Behavior, 96, 646-650.

Gardner, E. L. (2005). Endocannabinoid signaling system and brain reward: Emphasis on dopamine. Pharmacology, Biochemistry and Behavior, 81(2), 263-284.

Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A. & Uhla, G. R. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071,10-23.

González, B., Paz, F., Florán, L., Aceves, J., Erlij, D. & Floran, B. (2009). Cannabinoid agonists stimulate [3H]-GABA release in the globus pallidus of the rat when Gi proteinreceptor coupling is restricted. Journal of Pharmacology and Experimental Therapeutics, 328, 822-828.

Guegan, T., Cutando, L., Ayuso, E., Santini, E., Fisone, G., Bosch, F., Martinez, A., Valjent, E., Maldonado, R. & Martina, M. (2013). Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit. European Neuropsychopharmacology, 23(2), 146-159.

Jamshidy, N. & Taylor, D.A. (2001). Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.British Journal of Pharmacology, 134, 1151-1154.

Kirkham, T. C., Williams, C. M., Fezza, F., & Di Marzo, V. (2002). Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British Journal of Pharmacology, 136(4), 550-557.

Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S. & Avigliano, L. (2010). The endocannabinoid system and its relevance for nutrition. Annual Reviews of Nutrition, 30, 423-440.

Matias, I., Cristino, L. & Di Marzo, V. (2008). Endocannabinoids: Some like it fat (and sweet too). Journal of Neuroendocrinology, 20(1), 100-109.

Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A. & Melis, M. R. (2007). The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neuroscience Letters, 419 (3), 231-235.

Nederkoorn, C., Braet, B., Van Eijs, Y., Tanghe, A. & Jansen, A. (2006). Why obese children cannot resist food: The role of impulsivity. Eating Behaviors, 7, 315-322.

Pandolfo, P., Pamplona, F. A., Prediger, R. D. & Takahashi, R. N. (2007). Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2. European Journal of Pharmacology, 563(1–3), 141-148.

Paxinos, G. & Watson, C. (1998). The brain in stereotaxic coordinates. New York: Academic Press.

Perello, M., Chuang, J., Scott, M. M. & Lutter, M. (2010). Translational Neuroscience approaches to hyperphagia. The Journal of Neuroscience, 30(35), 11549-11554.

Quarta C., Bellocchio L., Manzini G., Mazza R., Cervino C., Braulke L., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., FanelliF., Reuss S., KlausS., Srivastava R., Monory K., Valerio A., Grandis A., de Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G. & Pagotto U. (2010). CB1 signaling in forebrain and sympathetic neurons is a key Determinant of endocannabinoid actions on energy balance. Cell Metabolism, 11, 273-285.

Ravinet-Trillou, C., Delgorge, C., Menet, C., Arnone, M. & Soubrié, P. (2004). CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity, 28, 640-648.

Sanudo-Pena, M.C., Patrick, S. L., Patrick, R.L. & Walker, J.M. (1996). Effects of intranigral cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system. Neuroscience Letters, 206, 21-24.

Soria-Gómez, E., Matías, I., Rueda-Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L. Di Marzo, V. & Próspero-García, O. (2007). Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. British Journal of Pharmacology, 151, 1109-1116.

Verty, A.N., McGregor, I.S. & Mallet, P.E. (2005). Paraventricular hypothalamic CB(1) cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)tetrahydrocannabinol. Neuropharmacology, 49 (8), 1101-1109.


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