How to Cite
Cruz Becerra, D., & Yomayusa G., N. (2003). Inmunoestimulación condicionada. Acta Colombiana De Psicología, (10), 23–32. Retrieved from

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The objective of this research was to observe if the granulocytic colony stimulating factor (G-CSF) effect, can be transferred to 1% glucose solution using classical conditioning paradigm. The design was oriented by the established parameters in the conditioned inmunosuppresion with ciclofosfamide and saccharine. Previously, the neutrophil levels were tested as an effect of: the drinking time reduction to 15 minutes per day, the 1% glucose solution ingest during 15 minutes per day, and of one single intraperitoneal doses of 20 mg/K of (G-CSF). Then the conditioning of G-CSF and 1% glucose solution was tested after one and two pairing sessions. The results are according with the Ader, R. et al. (1991) view, who refering to Solvason, B. et al. (1998) findings, state that there is not yet enough experimental evidence that support the inmunocompetence conditioning phenomenum.



Abbas, A., Lichtman, A. & Pober, J. (1995). Inmunología celular y molecular (2a. Ed.). España: Interamericana.

Ader, R. & Cohen, N. (1982). Behaviorally conditioned immunosuppression and systemic lupus erythematoso. Science, 215, 1534-1536.

Ader, R., & Cohen, N. (1993). Psychoneuroimmunology: conditioning and stress. Annual Review of Psychology, 44, 53-85.

Ader, R., Cohen, N., & Felten, D. (1995). Psychoneuroimmunology: Interaction between the nervous system and the immune system. The Lancet, 345, 99-103.

Ader, R., Felten, D. & Cohen, N. (1991). Psychoneuroimmunology (2a. Ed.). New York: Academic press.

Begley, C., Metcalf, D. & Nicola, N. (1988). Binding characteristics and proliferative action of purified G-CSF on normal and leukaemic human promyelocytes. Exp. Hematol, 16, 71-79.

Berdel, W., Danhauser-Rield, S.., Steinhasuer, G. & Winton, E. (1989). Various human hematopoietic growth factors stimulate clonal growth of non-hematopoietic tumor cells. Blood, 73, 80-83.

Black, P. (1995). Psychoneuroimmunology: brain and immunity. Cientific American Science & Medicine, 16-25.

Blalock, J. (1994). The syntax of immune- neuroendocrine communication. Immunology Today, 15, 504-510.

Borras, X. (1994). Condicionamiento clásico de las respuestas inmunológicas. Revista de Psicología General y Aplicada. 47, 429-439.

Chriusos, G. (1995). Seminars in medicine of the beth Israel, hospital, Boston: The hipotalamicpituitary-adrenal axix and immunogy- inflammation. The New England Journal of Medicine, 322, 1352-1359.

Clark, S. & Kamen, R. (1987). The human hematopoietic colony stimulating factors. Science. 236, 1229-1237.

Dexter, T. & Spooncer, E. (1987). Growth and differentiation in the hemopoietic system. Ann. Rev. Cell Biol. 3, 473-4841.

Donahue, R., Wang, E., Stone, D., Kamen, R.& Wong, G. (1986). Stimulation of hematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature, 321, 872.

Goodkin, K., Fletcher, M., & Cohen, N. (1995). Clinical aspects of psychoneuroimmunology. The Lancet, 345, 183-184.

Hardman, J., Limbird, L. & Goodman, A. (1996). Las bases farmacológicas de la terapéutica. (9ª. Ed.) México: McGraw-Hill Interamericana.

Klosterhalfen, W. & Klosterhalfen, S. (1983). Pavlovian conditioning of immunosuppression modifies adjunt arthritis in rats. Behavioral Neuroscience, 97, 663-666.

Maier, S., Watkins, M., & Fleshner, M. (1994). Psichoneuroimmunology: The interface between behavior, brain, and immunity. American psychologist, 49, 1004-1017.

Marad, A. & Rosenkranz, A. (1990). Guía para el uso de animales de laboratorio. Universidad Nacional de Colombia, Facultad de ciencias, Departamento de Farmacia.

Morstyn,G., Lieschke, G. & Cebon, J. (1989). Pharmacology of the colony-stimulating factors. Trends in Pharmacological Sciences, 10, 154-159.

Nicola, N., Metcalf, D., Matsumoto, M. & Johnson, G. (1983). Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony stimulating factor. J. Biol. Chem. 285, 9017-9023.

Reichlin, S. (1993). Neuroendocrine-immune interactions. The New England Journal of Medicine, 329, 1216-1253.

Savino, W., & Dardenne, M. (1995). Immuneneuroendocrine interactions. Immunology Today, 16, 318-321.

Solvason, B., Ghanta, V. & Hiramoto, R. (1988). Conditioned augmentation of natural killer cell activity. Independence from nociceptive effects and dependence on interferon-beta. J Immunol. 15, 140, 661-665.

Souza, L., Boone, T. & Gabrilove, J. (1986). Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science; 232, 61-65.

Stites, D. & Terr, A. (1993). Inmunología básica y clínica (7a. Ed.). Mexico: Manual Moderno.

Ulich,T., Del Castillo,J. & Souza,L.M. (1988). Kinetics and mechanisms of recombinant human granulocyte colony-stimulating factorinduced neutrophilia. American Journal of Pathol, 133, 630-638.

Vives, J., & Aguilar, J. (1997). Manual de técnicas de Laboratorio en hematología. (2 Ed) Barcelona: Masson SA.

Welte, K., Bonilla, M., Gabrilove, J., Gillio, A. & Potter, G. (1987). Recombinant human granulocyte colony-stimulating factor in vitro an in vivo effects on myelopoiesis. Blood, 13, 17-30.


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