Efectos de la administración crónica de cocaína (30 mg/kg) sobre la conducta materna y de la administración prenatal de cocaína y de la conducta materna, sobre la conducta emocional y la ingesta de cocaína (30 mg/kg) y agua en ratones adultos.

Resumen

The chronic administration effects of cocaine (30 mg/kg) (s.c.) were analysed in gestation period on the maternal behaviour (M) on female mice and the effects of prenatal chronic treatment of cocaine (30 mg/kg) and the CM (biological mother vs. nurse) in the emo­tional behaviour and in the cocaine uptake 30 mg/kg and water in the adult female and male mice. 14 females in gestation period were aleatorily assigned into two groups, a one group to daily cocaine application (30 mg/kg) and the second group to saline solution. From the first day to twelve day of pregnancy. After parturition the cross- nursing was made, each mother kept biological young two males and two females, and four fosters young . The EB of young and mother was treated in the 5 week. The first evaluation and the cocaine uptake were not differential because of the experimental treatment. Effects of the prenatal treatment in the emotional behaviour to long term were found (second evalu­ation) and potencies for the free uptake of cocaine (30 mg/kg) mainly in the females, which were more anxious because of the highest water uptake and the least exploration. The prenatal treatment with cocaine (30 mg/kg) was stronger that the bring up conclusion in the emotionality and the effects to young females more the males.

Palabras clave:

Experimental Psychology Psychopharmacology Drogaddiction Cocaine

Citas

Bernard, J.F., Bandier, R. (1998) Parallel circuits for emotional coping behaviour: New pieces in the puzzle. Journal of Comparative Neurology. Vol. 401, no. 4, pp. 429-436

Blanchard, C., Blanchard, R., De Padua, A., Veniegas, R., J., Rodger, J. y Shepherd, J. (1992) MK-801 produces a reduction in anxiety-relates antipredator defensiveness in male and female rats and gender-dependent increase in locomotor behavior. Psychopharmacology. 108:352-362.

Bland-Stewart, L.M., Seymour, H.N., Beeghly, M. y Frank, D.A.(1998) Semantic development in African-American children prenatally exposed to cocaine. Sernin Speech Language. 19 (2): 167-86.

Carlos, E.A. ( 1998) A prospective longitudinal study of attachment disorganisation disorientation. Children Development. Aug, 69(4) 1107-28.

Carter, B.L. ( 1989) A counselling the pregnant or lactating patient. ASHP-Midyear-Clinical-Meeting; 1989; 24 (Dec); 43-60

Carter, C.S ., Lederhndler, P. y Kirkpatrick, B. ( 1997) The integrative neurobiology of affiliation. Introduction. Annual New York Academy Sciences. Jan 15, 807 XIII-XVIII.

Chasnoff, I. J. (1992) Cocaine Pregnancy and growing child. In current problems in paediatrics. Chicago: Mosby Yearbooks.

Chen, W.J., Andersen, K..H., West, J.R. (1994) Alcohol-induced brain growth restrictions (microencephaly) were not affected by concurrent exposure to cocaine during the brain growth spurt. Teratology. Sep; 50(3): 250-5.

Clement, Y., Chapouthier, G. (1998) Biological bases of anxiety. Neuroscience and Biobehavioral Reviews. vol. 22, no. 5, pp. 623-633.

Cortese, B .M., Krahl, S.E., Berman, R.F., Hannigan, J.H. ( 1997) Effects of prenatal ethanol exposure on hippocampal theta activity in the rat. Alcohol. Vol. 14, no. 3, pp. 231-235.

Claro, F., Perez-Izquierdo, M.A., Del-Abril, A., Segovia, S., Guillamon, A., Del-Cerro, M.C. (1994) MBR: a computer programs to record and analyse parental behavior in rodents. Physiology Behavior. Nov 56 (5). 1069-73.

Cladji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M. and Meaney, M. J. (1998) Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Processes Natal Academy Science USA. Apr 28, 95(9) 5335-40.

D'amato, F.R., Cabib, S., Ventura, R. Orsini, C. (1998) Long-term effects of posnatal ma­ nipulation on emotionally are prevented by maternal anxiolytic treatment in mice. Development Psychobiology. 32, 225-34.

Dess, N. K. (1991) Ingestion and emotional health. Human Nature. 2, 235-269.

Dess, N. K. y Minor, T. R and Brewer, J. (1989) Suppression of feeding and body weight by inescapable shock: modulation by quinine adulteration, stress reinstatement and controllability. Physiology and Behavior, 45,975-983.

Dess, N.K. y Chapman, C.D. (1990) Individual differences in taste. Body weight and depression in the helplessness rat model and in humans. Brain Research Bulletin. 24, 669-676.

Diaz, J.L. (1985) Análisis estructural de la conducta. Universidad Nacional Autónoma de Mexico. Dirección general de publicaciones. Mexico D. F.

Dominguez, H.D., Lopez, M.F., Chotro, M.G., Molina, J.C. ( 1996) Perinatal responsiveness to alcohol's chemosensory cues as a function of prenatal alcohol administration during gestational days 17-20 in the rat. Neurobiology Learn and Memory, vol. 65, no. 2, pp. 103-112.

Dutriez-Casteloot, I., Bernet, F., Dedieu, J.F., Croix, D., Laborie, C., Montel, V., Lesage, J. Beauvillain, J.C., Dupouy, J.P. (1999) Hypothalami e-pituitary-adren cortical and gonadal axes and sympathoadrenal activity of adult male rats prenatally exposed to morphine Neuroscience-Letters [Neurosci.­ Lett.] 1999 vol. 263, no. 1, pp. 1-4.

Ellsworth, JA., Andersen, C. (1997) Adoption by captive parturient rhesus macaques: Biological vs. adopted inf ants and the cost of being a "twin" and rearing "twins", American Journal of Primatology. 43,259-64.

Fernandez-Teruel, A., Escorihuela, R., Driscoll, P., Tobeña, A., & Batting, K. ( 1992) Differential effects of early stimulation and/or perinatal flumazemil treatment in young Roman Low and Hight avoidance rats. Psychopharmacology. I 08, 170-176.

Fiala, B., Snow, F.M., Greenought, W.T. (1977) Impoverished Rats Weigh More than Enriched rats because they eat more. Development Psychobiology .. 1 O: 537-541.

Field T.(1998) Maternal depression effects on infants and early interventions. Prevention Medical. March- Abril, 27 (2): 200-3.

Flint, J., Corley, R., DeFries, J.C., Fulker, D.W., Gray, J.A., Miller, S., Collins, A.C.A (1995) simple genetic basis for a complex psychological trait in laboratory mice. Science U'ash. vol.269,no. 5229,pp. 1432-1435.

Goodwin, O.A., Bliven, T., Kuhn, C., Francis, R., Spear, L.P. (1997). Immediate early gene expression to examine neuronal activity following acute and chronic stressors in rat pups: Examination of neurophysiological alterations underlying behavioral consequences of prenatal cocaine exposure. Physiology Behavioral. vol. 61, no. 6, pp. 895-902.

Gouldsboroug, Y., Black, V., Johnson, I.T. Asthon, N. (1998) Maternal nursing behavior and delivery of milk to the neonatal spontaneously hipertensive rat. Acts Physiology Scandinavia. 162, 107-14.

Hecht, G.S., Spear, N.E., Spear, L.P. (1998) Alterations in the reinforcing efficacy of cocaine in adult rats following prenatal exposure to cocaine. Behavioral Neuroscience. vol. 112, no. ·2, pp. 410-418.

Hendrie, C.A., Weiss, S.M., Eilam, D. (1996) Exploration and predation models of anxiety: Evidence from laboratory and wild species. Pharmacology Biochemical Behavioral. vol. 54, no. 1, pp. 13-20.

Hill, S Y., y Poewell, B.J. (1976) Cocaine and Morphine Self-Administration: Effects of Differential Rearing. Pharmacology Biochemical Behavior. 5: 701-704.

Hughes, H.E., Donohue, L.M., Dow Edwards, D.L.(1996) Prenatal cocaine exposure affects the acoustic startle response in adult rats. Behavior Brain Research. vol. 75, no. 1-2, pp. 83-90.

Insel, T.R., Winslow, J.T., Wang, Z.X., Young, L., Hulihan, T.J.(1995) Oxytocin and the molecular basis of monogamy. Advanced in Experimental Medicine Biological. 395: 227-34.

Jansson, L., Svikis, D, Lee J., Paluzz, P., Rutligiano, P. and Hackerman, F.( 1996) Pregnancy and Addiction. Journal of Substance Abuse Treatment, 13, 321-329.

Jones, S. y Brain, P.(1985) An illustration of simple sequence analysis with reference to the agonistic Behavior of four trains cepas Sprains of laboratory mouse. Behavior processes. 11, 365-388.

Kosofsky, B.E. (1998) Cocaine-induced alterations in the neuro-development. Seminary speech-language. 19, 109-21.

Kurnianto, E., Shinjo, A. y Suga, D. (1998) Prenatal and posnatal maternal effects on body weight in cross-fostering experiment on two subspecies of mice. Experimental Animal. 47, (2) 97-103.

Laviola, G., Petruzzi, S., Rankin, J., and Alleva, E. ( 1994) Induction of maternal behavior by mouse neonates: influence of dam parity and prenatal oxazepam exposure. Pharmacology and Biochemical Behavior. Dec; 49(4): 871- 6.

Lidow, M.S. (1995) Prenatal cocaine exposure adversely affects development of the primate cerebral cortex. Synapse. vol. 21, no. 4, pp. 332-341.

Matera, C. Warren, W., Moomjy, M., Find, D. and Fox, H. ( 1990) Prevalence of the use of cocaine and other substances in an obstetric population. American Journal of obstetric and gynecology. 163, 797-801.

McElhatton, P.R.(1994) The effects of benzodiazepine use during pregnancy and lactation. Reproduction Toxicology. Nov-Dec; 8 (6): 461- 75 . Niesink, R. J .M., Vanderschuren, L.J .M.J ., VanRee, J.M. (1996). Social play in juvenile rats after in utero exposure to morphine. Neurotoxicology. vol. 17, no. 3-4, pp. 905-912.

Panksepp, J., Nelson, E., Siviy, S. (1994) Brain opioids and mother-inf ant social motivation. Acta Paediatrics Supply. Jun 397. pp 40-6.

Perez A. y Correa, E. ( 1994) Consumo de sustancias Psicoacti vas en Santa Fe de Bogotá: Alcaldía Mayor de Bogotá: Unidad Coordinadora de Prevencián Integral. Colombia. Guadalupe.

Plan Municipal de prevención en Medellín (1994) Hospital Universitario de San Vicente de Paul: Departamento de toxicología. Alcaldía de Medellín. Compendio de farmacología y alcoholismo. Medellin. Colombia.

Prasad, A., Henry, M., Prasad, C. (1996) Heterogeneity in the performance of outbreed Sprague-Dawley rats in an elevated-plus maze test: A possible animal model for anxiety disorder. Life Sciences. vol. 59, no. 18, pp. 1499-1506.

Rex,T., Voigt, H., Voits, H. and Fink, F. ( 1998) Pharmacological Evaluation of a Modified Open-Field Test Sensitive to Anxiolytic Drugs. Pharmacology Biochemistry and Behavior. vol. 59, no. 3, pp. 677-683.

Ritz, MC. Garcia, J.M., Protz, D., Rael, AM y George, F.R. (1994) Ethanol reinforced behavior in P, Np, HAD y LAD rats: Different genetic regulation of reinforcements and motivation. Behavioral Pharmacology. 5, 521-531.

Rodgers, R.J., Cao, B.J. Dalvi, A., Holmes, A (1997). Animal models of anxiety: An ethnological perspective. Brazilean Journal Medical Biology Research. Vol. 30, no. 3, pp. 289-304.

Rodríguez, E., Duque, L. Y Rodríguez, J (1993) Estudio Nacional sobre consumo de Sustancias Psicoactivas en Colombia. 1992.

Dirección Nacional de estupefacientes. Minjusticia. Fundación Santa Fe de Bogotá. Fundación Escuela Colombiana de Medicina.

Rosenblatt, J.S. (1994) Psychobiology of maternal behavior: contribution to the clinical understanding of maternal behavior among humans. Acta Paediatrics Supply. Jun; 397: 3-8.

Rosenblatt, J.S., Wagner, C.K., Morrell, JI. (1994). Hormonal priming and triggering of maternal behavior in the rat with special reference to the relations between estrogen receptor binding and ER mRNA in specific brain regions. Psychoneuroendocrinology. 19 (5-7): 543-52.

Santacruz, M. P. (1998) Línea de investigación en psicofarmacología de la cocaína y el alcohol en ratas y ratones. Acta Colombiana de Psicología. 1,71-103.

Silverman, M. (1976) Animal Behavior, the rat in laboratory. New York: Lancet.

Smith, J., Neil, J.C. y Costali, B. (1997) Postwaning housing conditions influence the behavioral effects of cocaine and d-amphet­ amine. Psychopharmacology. 131, 23-33.

Smith, J.K. Neil, J.C. y Costall, B. (1997) Bidirectional Effects of Dopamine 02 receptor antagonists on responding for a conditioners Reinforce. Pharmacology Biachemistry Behavior. 57, 843-849.

Wang-MW; Crombie DL., Mais, DE., Hayes, JS., Heap, RB (1995) Anti-progesterone antibody administration and the impairment of postpartum maternal care in mice. Journal of Endocrinology. May; 145(2): 363-9.

Weinberg, J., Kim, C., Kwon, P. and Yu, W. ( 1995). Early handling can attenuate adverse effects of fetal ethanol. Alcohol. vol. 12, no. 4, pp. 317-327.

Weinberg, M.K. y Troni ck, E.Z.(1998) The impact of maternal psychiatric illness on infant development. Journal Clinical Psychiatry. 59 (2) 53-61.

Wilson, A. Neil, J. and Costall, B. (1996) The 5-HTla Receptor agonist 8-0H- DPAT re­ duces ethanol intake and maintained behavior in female Sprague-Dawley Rats (l996) Alcohol. 13 407-413.

Yirmiya, R., Tio, D.L., Taylor, A.N. (1996). Effects of fe tal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-I beta in young adult rats. Brain Behavior Immunology. vol. 10, no. 3, pp. 205-220 .

Tejedor-Real, P., Costela, C., Gilbert-Rahola, J. (1997) Neonatal handling reduces emotional reactivity and susceptibility to learned helplessness. Involvement of catecholaminergic systems. Life Sciences. 62, 1, pp.37-50.

Torres de Galvis, My Murelle, F.(1987). Estudio Nacional sobre alcoholismo y sustancias que producen dependencia. Medellín. Universidad de Antioquia. Facultad de salud Pública.

Weinraub, Z., Bental, Y., Olivan, A., Rotchild, A. (1998) Neonatal withdrawal syndrome and behavioral effects produced by maternal drug use. Addiction Biology. Vol. 3, pp 159-170.