Cómo citar
Santacruz , M. del P. (1998). Línea de investigación en psicofarmacología de la cocaína y el etanol en ratas y ratones. Acta Colombiana de Psicología, (1), 71-103. Recuperado a partir de https://actacolombianapsicologia.ucatolica.edu.co/article/view/633

Resumen

I present a brief summary of the research, about two drugs of great abuse in Colom­bia: Cocaine and alcohol, carried out at Universidad Católica de Colombia's labora­tory of experimental psychology. By means of animal model, we have evaluated the effects of different doses of cocaine and alcohol (0.1,1.0,10 y 20,mg/kg) on several parameters of aggressive, emotional, and social behavior in adult female and male rats and mice, as in sons of addicted mothers along gestation time. Moreover we have assessed the effects of acute administration (one injection), chronic administration (ten to twelve consecutive injections), withdrawal syndrome with the same parame­ters, and long term persistence of pharmacological effects. The results of the re­search are presented, as well as the titles of investigations recently started . 

Licencia

Derechos de autor 1998 María del Pilar Santacruz

Creative Commons License
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0.

Citas

Ades, C. y Oliveira, B. (1984). Are conditioned stimuli determinant of oriented exploratory behavior in the rat? Behavior and Neurobiology. 41. 63-70.

Beltrán. N. Arciniegas, J. Fadul. M. Llanos, C. Llanos, A. Lizcano. F. Vélez, E, Martínez. M., Portela. G. y Ángulo, S. (1989). Prevalencia de farmacodependencia en estudiantes de sexto año de bachillerato de colegios oficiales y privados. Salud Uninorte. 4-5, 53-62.

Birke, L. y Sadler, D. (1986). Patterns of exploratory behaviour in the spiny moue acomys canirinus. Behavior and neurobiology. 45, 88-106.

Blancard, R. y Yudco E. (1993) Alcohol. Aggression and the neuromotriz behavior. Journal of studies on alcohol. Hawaii, Honolulu. (11) 146- 155.

Cano. A. (1995). Psicología de las drogodependencias, Madrid: facultad de Psicología, Universidad complutense.

Cahuana, A. : Gairi. J. y López, C. (1982). Embriofetopatia Alcohólica. Estudio de 17 casos. Barcelona, Anuario español de Pediatría. 4, pp 315-321.

Cedric. S. y Alan, R. (1992). Farmacología. Buenos Aires: Médica Panamericana.

Clark, J. & Hawley, K. (1989). The encyclopedy of chemistry. Princeton. Corel Publication.

Coles, B., Platzman, K. (1993). Development in children prenatally exposed to drugs and alcohol. Journal addiction, Nov 28 (13), 1393-433.

Cole, B., Cador. M., Stimus, L., River, C., River J., Vale. W, Le Moral, M. y Koob, G. (1990). Critical role of the hypothalamic pituitary adrenal axis in amphetamine induced sensitization of behavior. Life sciences. 47, 1715-1720.

Córdoba, D ( 1991 ). Tratado de toxicología. Mexico. Trillas.

Costall, B., Kelly, E., Naylor. R. y Onavi. E. (1989). The action of nicotine and cocaine in a mouse model of anxiety. Pharmacology, Biochemistry and behavior: 33, 197-203.

Crawley, J. (1985). Exploratory behavior models of anxiety in mice. Neuroscience and behavioral reviews. 9, 37-41.

Darmani, Nissar A., Hatdìeld. M. Gary G., Carter E. Walter H., Martin. H. & Billy R. (1990). Acute and Chronic effects of cocaine on isolation induced aggression in mice. Psychopharmacology. 1 37-40.

Das, G (1994). Cocaine abuse and reproduction journal Clinical Pharmacology. 32 (1):7-11.

Domjan. M. (1996). Teratology List Science. American Health. june.

Espert, R., Navarro, J., Salvador, A., & Simón, V. ( 1993 ). Effects of morphine hydrochloride on social encounters between male mice. Aggressive behavior.19, 337-383.

Esposito, R., Perry, W, Kornetsky, C. (1980). Effects d-ampheta-mine and naloxone on brain stimulation reward. Psychopharmacology. 69. 187-191.

Fabre-Nys, c., Meler, R., Keverne, E. (1982). Opiate antagonists stimulate affiliative behavior in monkeys, Pharmacol biochem behavior 16: 653-659.

Frick, S y Dow E. (1995). The effects of cocaine on cerebral metabolic function in peri weanling rat. Developmental Brain Research. 88(2): 158-170.

George. F y Ritz, M. (1990). Cocaine produces locomotor stimulation in SS but not LS mice: Relationship to dopaminergic function. Psychopharmacology, 101. 18·22.

Geyer, M. Petersen, Y y Rose, G. (1980). Effects of serotoninergic lesions on investigatory responding by rats in a holeboard. Behavior and Neurobiology. 30, 160-177.

Goleman, D. (1996) Brain images of addiction in action show. Its neural basis. New York. Times, august 13th, pg. C3.

Gómez, A. (1987). Cocaina. Surgimiento y evolución de un mito. Santafé de Bogotá Catálogo científico.

Kalivas, P, Duffy P, Dumars, L. & Skinner, C. (1988). Behavioral and Neurochemical effects of acute and daily cocaine, administration in rats. Journal of pharmacology experimental. 245. 485-492.

Kalivas, P y Duffy, P (1989). Similar effects of daily cocaine and stress on mesocorticolimbic dopamine neurotransmission in the rat. Biol. Psychiatry 25. 913-928.

Karzung, B. (1991). Farmacología básica y clínica. México: Manual Moderno.

Kiyatkin, E. (1994) Change in dopamine-de­pendent electrochemical signal in the nucleus accumbens associated with re­ peated cocaine injections in rats. Neuro­ science. Vol. 78, ISS 1-2.

Kovacs, G., Sarnyai, Z .. Babarczì. E., Szabo, Ci. y Telegdy, G. ( 19()()). Tl1e role of oxytocin­ dopamine interactions i11 cocaine-induced locomotor hyperactivity. Neuropharmacology. 29, 365-368.

Lister, R. ( 1987). The use of a plus Maze to measure anxiety in the mouse. Psychopharmacology. 92, 180-185.

Miczek. K . O’Donell, J. (1978). Intruderevoked aggression in isolated and non-iso­lated mice: effects of psychomotor stimulants and L-DOPA. Psychopharmacology. 57:47-55.

Mitchell, PJ. & Fletcher. A. (1993). Venlafaxine exhibits pre-clinical antídepressant activity in the resident-intruder social interaction paradigm. Neuropharmacology. 32. 1001- 1009.

Melgarejo, M. (1987) Memorias seminarios alternativas de tratamientos y rehabilitación en farmacodependencia y alcoholismo. Ministerio de salud, división de salud mental. Bogotá.
Pérez, A. (1987). Cocaína. Surgimiento y evolución de un mito. Bogotá. Catalogo científico.
Ritz, M., Lamb, R. Goldberg, S., Kuhar, M. (1987) Cocaine receptors Dopamine transporters are related to self-administration of cocaine. Science. 273. 1219-1223.

Rodríguez, E., (1992) Estudio Nacional Sobre consumo de sustancias psicoactivas. Santafé de Bogotá.

Rogerio, R. Takahashi. R. (1990). Some calcium channel antagonists have no effect on the open field behavior of rats do they interact with cocaine. Med.Biol.Res. 23, 1153-1151.

Rump. A., Theisohn. M., Klaus. W. (1998). The pathophysiology of cocaine carditoxicity. Forensic science, 2. (71), 103-15.

Santacruz, M.P. Castro, M. Gil. Z., Quintero.]. y Silva, G. (1996). Efectos de la administración aguda y crónica de clorhidrato de cocaína (0.1. 1.0, y 10 mg/kg.), evaluación de abstinencia y de la permanencia de los efectos farmacológicos a largo plazo en las conductas agonísticas del ratón. Tesis para optar el título de Psicólogo. Universidad Católica de Colombia.

Taylor. J; Harrys. N; Vogel, W. (1990) Voluntary alcohol and cocaine consumption in Low and High stress plasma catecholamine responding rats. Pharmacology biochemistry and behavior. 37 359-363.

Descargas

La descarga de datos todavía no está disponible.
Sistema OJS 3 - Metabiblioteca |